Josef Jampílek – personal webpage

Prof. PharmDr. Josef JAMPÍLEK, Ph.D.

 

Education and academic qualifications

2017Full Professor of Medicinal Chemistry – Comenius University in Bratislava, Slovakia
2009Associate Professor – University of Veterinary and Pharmaceutical Sciences Brno, Faculty of Pharmacy, Czech Republic (Medicinal Chemistry)
2004PharmDr., Ph.D. – Charles University, Faculty of Pharmacy, Czech Republic (Medicinal Chemistry)
2000M.Sc. – Charles University, Faculty of Pharmacy, Czech Republic (Pharmacy)

Professional and Management Training

2011–2012Effective Professional Communication, Conflict Resolution and Leadership – DEVELOR Czech s.r.o., Czech Republic
2011Creative Thinking Course – IMPRoPACT, s.r.o., Czech Republic
2008Project Control – EXPERTIS Praha s.r.o., Czech Republic
2008Negotiation –DEVELOR Czech s.r.o., Czech Republic
2006–2007Senior Management Training “Z-Leader” – EXPERTIS Praha s.r.o., Czech Republic
2008Measurement and Interpretation of Vibrational Spectra, FT-IR Spectroscopy, Omnic and TQ Analyst – Ioannes Marcus Marci Spectroscopic Society & Nicolet  CZ s.r.o., Czech Republic
2007Sensors: Prague Centre for Innovations in Analytical Chemistry, Czech Republic
2007GxP Requirements for R&D – G.M.Project s.r.o., Czech Republic
2006GMP for API Manufacturing – G.M.Project s.r.o., Czech Republic
2005Quality Control – G.M.Project s.r.o., Czech Republic
2005–2010Waters Data Schools of Liquid Chromatography, Empower Admin Schools – WATERS GmbH, Prague, Czech Republic
2004Clinical Drug Trial – Clinical Trial Association & ARCOmed s.r.o., Czech Republic

 

Professional experience

2016–presentAssociate Professor, Professor – Head of Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University in Bratislava, Slovakia
2009–presentExternal lecturer – Institute for Postgraduate Medical Education Prague, Czech Republic
2006–2016Different positions: Assistant Professor, Associate Professor – Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
2006–2007External lecturer – Department of Pharmaceutical Chemistry and Drug Control & Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Czech Republic
2004–2011Different positions: Senior Specialist, Head of Laboratory, Senior Scientist – R&D Division, Zentiva Prague, Czech Republic
2000–2003Scientist – Research Centre of Structure and Mechanism of Action of Potential Drugs, Faculty of Pharmacy, Charles University, Czech Republic & Zentiva Prague, Czech Republic

 

Teaching activities

  • Master courses of pharmacy: lecturer of Medicinal Chemistry (Guarantor of the Course), Drug Analysis, Molecular Principles of Drug Design, Pharmaceutical Analysis in Industry
  • Supervisor of defended 15 Diploma students (M.Sc.) and 9 Rigorous students (PharmDr.) and 4 Ph.D. students in Medicinal Chemistry and Safety & Quality of Drugs

 

Research activities

  • Design, synthesis and structure-activity relationships of potential anti-infectives and antineoplastics
  • Design, synthesis and structure-activity relationships of potential photosynthesis inhibitors
  • Design, synthesis and structure-activity relationships of potential transdermal enhancers
  • Study of physicochemical properties of potential drugs and drug polymorphism
  • Study of in vitro bioavailability, nanoparticles and ADME
  • Pharmaceutical analysis and solid-state analytical techniques

 

Professional stays abroad

2017Bosch Institute, University of Sydney, Australia (visiting professor)
2017Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Slovenia (visiting professor)
2016Key Laboratory of Chemistry for Natural Products of Chinese Academy of Sciences, Guiyang, China (visiting professor)
2016, 2017School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China (visiting professor)
2016Department of Organic Chemistry, Institute of Chemical Technology and Engineering, Poznan University of Technology, Poland (visiting professor)
2016Institute of Medicinal Chemistry, University of Veterinary Medicine and Pharmacy in Košice, Slovakia (visiting professor)
2015Institute of Inorganic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Poland (visiting professor)
2014Department of Pharmaceutical and Toxicological Chemistry, Faculty of Pharmacy, South Kazakhstan State Pharmaceutical Academy, Shymkent, Kazakhstan (visiting professor)
2014, 2015Department of Biochemistry and Neurobiology, Faculty of Materials Science, AGH University of Science and Technology, Krakow, Poland (visiting professor)
2014Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kazakh National Medical University, Almaty, Kazakhstan (visiting professor)
2009–presentInstitute of Chemistry, University of Silesia in Katowice, Poland (visiting professor)
2000Medicinal Chemistry Institute, Heidelberg University, Germany (research fellowship)

 

Other academic activities, research projects, grants

2016–presentMember of Doctoral Study Board: Medicinal Chemistry (Faculty of Pharmacy, Comenius University in Bratislava, Slovakia)
2016–presentMember of State Examination Commissions on undergraduate and doctoral level (Faculty of Pharmacy, Comenius University in Bratislava, Slovakia)
2015, 2016Member of State Examination Commission on undergraduate level (Pharmacy Programme, University of Veterinary Medicine and Pharmacy in Košice, Slovakia)
2013, 2016Member of State Examination Commission on doctoral level: Drugs & Biomaterials (Faculty of Chemical Technology, Institute of Chemical Technology in Prague, Czech Republic)
2013–2016Coordinator of Paul Ehrlich MedChem Euro-Ph.D. Network at the Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
2013–presentMember of Doctoral Study Board: Safety & Quality of Drugs (Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic)
2012–2013R&D Coordinator at the Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
2009–presentMember of Doctoral Study Board: Medicinal Chemistry (Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic)
2009–presentMember of State Examination Commissions on undergraduate and doctoral level (Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic)

Selected grants

2016Investigation of Newly Synthesized Antibacterial Chemotherapeutics.(IGA VFU Brno 311/2016/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group
2015Innovative Composite Biomaterials Contained Bioactive Calcium Phosphates (LIDER/037/481/L-5/13/NCBR). The National Centre for Research and Development in Poland, member of research group
2015Anti-Invasive Activity of Novel Antimicrobial Chemotherapeutics (IGA VFU Brno 304/2015/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, principal investigator
2015Evaluation of Alaptide Derivatives as Potential Modifiers of Transdermal Penetration (IGA VFU Brno 302/2015/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group
2014–2017Matrix Systems for Healing of Skin Defects for Human and Veterinary Use (TAČR TA04010065). Technology Agency of the Czech Republic, member of research group
2014Study of Antimicrobial Properties of Newly Synthesized Prospective Chemotherapeutics (IGA VFU Brno 52/2014/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group
2014Synthesis of Carboxamides of Kynurenic Acid as Biologically Active Compounds (IGA VFU Brno, 37/2014/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, principal investigator
2014Improving Qualification of Students of Ph.D. Educational Programs & Postdoctorates of Agricultural and Veterinary Branches through Engagement in Multidisciplinary Interuniversity Teams (MSM Project No. C3/2014). Centralized Development Project of the Ministry of Education of the Czech Republic in 2014. Member of research group
2013–2017Small Molecules in Biomedical Research (APVV-0516-12). Slovak Research and Development Agency. Member of research group
2012Synthesis of Hydroxynaphthyl Carboxamides as Biologically Active Compounds (IGA VFU Brno 96/2012/FaF). Internal Grant Agency of the University of Veterinary and Pharmaceutical Sciences Brno, member of research group
2011–2014Nanotechnology Approaches for Drug Delivery Across Blood-Tissue Barriers (GAČR P304/11/2246). Czech Science Foundation of the Czech Republic, principal investigator
2003Chalcones and Their Analogues as Potencial Drugs (FRVŠ 2970/G3/2003). University Development Fund of the Ministry of Education of the Czech Republic, co-investigator
2003Continuation of Potential Antituberculotics and Antimycotics Preparation (FRVŠ 2998/G6/2003). University Development Fund of the Ministry of Education of the Czech Republic, principal investigator
2002Completion of Potential Antituberculotics and Antimycotics Series Synthesis (FRVŠ 2245/G4/2002). University Development Fund of the Ministry of Education of the Czech Republic, principal investigator
2000–2004Research Centre for Structure and Mechanism of Action of Potential Drugs (LN00B125). Ministry of Education of the Czech Republic, member of research group
1999–2004Development, Preparation and Drug Technology (MSM 111600001). Research Aims of the Ministry of Education of the Czech Republic, member of research group
1998–2000Biologically active derivatives of pyrazine and pyridine (GAUK 026/1998/B-CH/FaF). Grant Agency of the Charles University, member of research group

 

Non-university activities

  • Member of the panel “Chemical and Biochemical Transformations” of the Expert Board of the Czech Science Foundation (2015–2017)
  • Ad hoc grant reviewer in the branch of Medicinal Chemistry and Pharmacology: Haimen Institute of Science and Technology (2016, 2017), Hong Kong Health and Medical Research Fund (2016, 2017), Polish National Centre for Research and Development (2015, 2016), Scientific Grant Agency of the Ministry of Education of the Slovak Republic & the Slovak Academy of Sciences (2015), Fulbright Visiting Scholar Program (2014, 2015), Hungarian Scientific Research Fund (2014, 2015), Slovak Research and Development Agency (2012, 2015, 2016), Internal Grant Agency of the Ministry of Health of the Czech Republic (2011–2013), Technology Agency of the Czech Republic (2010–2013), South African Medical Research Council (2010–2011)
  • Member of the organizational or scientific committees of conferences, e.g., 3rd International Conference on Nanomedicine, Drug Delivery, and Tissue Engineering, Hungary (2018), 7th Annual Symposium of Drug Delivery Systems, Czech Republic (2017), 6th World Conference on Physico Chemical Methods in Drug Discovery and Development, Croatia (2017), 46th EuroCongress on Drug Synthesis and Analysis, Slovakia (2017), 2nd International Conference on Nanomedicine, Drug Delivery, and Tissue Engineering, Spain (2017), 20th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-20) (2016), 5th IAPC Meeting Emerging Technologies in Drug Discovery and Development”, Macau-China (2016), Chair of the 8th Central European Conference "Chemistry towards Biology", Czech Republic (2016), Chair of the World Congress on Recent Advances in Nanotechnology, Czech Republic (2016), International Conference on Nanomedicine, Drug Delivery, and Tissue Engineering, Czech Republic (2016), World Conference on Physico-Chemical Methods in Drug Discovery and Development, Croatia (2015), Nanomaterials and Nanotechnology Meeting, Czech Republic (2015, 2017), 7th Central European Conference "Chemistry towards Biology", Poland (2014), International Symposium and Workshop on Environment and Health, Czech Republic (2012, 2013), Chromatographic Methods of Investigating the Organic Compounds, Poland (2012–2017), Drug Synthesis and Analysis, Czech Republic (2008, 2011, 2015)
  • Member of the Editorial Boards of Medicinal Chemistry (since 2015), ChemistrySelect (since 2015), Open Pharmaceutical Sciences Journal (since 2015), ADMET & DMPK (since 2014), Journal of Bioequivalence & Bioavailability (since 2013), Military Medical Science Letters (since 2011)
  • Guest Editor of Monatshefte für Chemie (2017, 2018), Molecules (2017), Current Medicinal Chemistry (2017–2018), Molecules (2016), Current Organic Chemistry (2016–2017), BioMed Research International (2014–2015), ADMET & DMPK (2014), Current Pharmaceutical Design (2010–2011)
  • Ad hoc reviewer, e.g., Acta Chromatographica, Anti-Cancer Agents in Medicinal Chemistry, Arabian Journal of Chemistry, ASC Combinatorial Science, Biomaterials,Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Central European Journal of Chemistry,Chemical Biology & Drug Design, Chemical Engineering Journal, ChemMedChem, Chemistry Central Journal,Combinatorial Chemistry & High Throughput Screening, Current Pharmaceutical Design, Current Organic Synthesis, Drug Discovery Today, European Journal of Medicinal Chemistry, European Journal of Organic Chemistry, Expert Opinion on Drug Discovery, Frontiers in Life Science, International Journal of Medicinal Chemistry, Journal of Applied Biomedicine, Journal of Biochemical & Molecular Toxicology, Journal of Biomolecular Structure & Dynamics, Journal of Chemical Technology & Biotechnology, Journal of Combinatorial Chemistry, Journal of Molecular Structure, Journal of Nanoscience and Nanotechnology, Letters in Drug Design & Discovery, Letters in Organic Chemistry, Medicinal Chemistry, Molecules, Monatshefte für Chemie, Pest Management Science, Pharmaceutical Research, RSC Advances,Steroids, Tuberculosis
  • Member of Working Group on New TB Drugs (since 2015), International Association of Physical Chemists (since 2014), Czech Pharmaceutical Society – Synthetic Drugs Section (since 2002) and Czech Chemical Society – Organic and Bioorganic Section (since 2002)

 

Most significant professional accomplishments

  • Invited/plenary lectures on international medicinal chemistry or pharmaceutical analysis conferences, e.g., 2nd International Conference on Applied Chemistry, Egypt (2017), 7th Annual World Congress of Nano Science & Technology, Japan (2017), International Conference on BioNano Innovation, Australia (2017), 7th Annual Symposium of Drug Delivery Systems, Czech Republic (2017), International Conference on Progressive PharmSciences, Spain (2017), 5th International Symposium on Edible & Medical Plant Resources and the Bioactive Ingredients, China (2016), 6th Annual World Congress of Nano Science & Technology, Singapore (2016), Pharmaceutical Chemistry-2016, Germany (2016), International Conference on Nanomedicine, Drug Delivery, and Tissue Engineering, Czech Republic (2016), Annual Congress of International Drug Discovery Science & Technology, China (20152017), Annual Symposium of Drug Delivery System, China (2015, 2016), 24th Central European Conference ECOpole’15, Poland (2015), 4th World Conference on Physico-Chemical Methods in Drug Discovery and Development, Croatia (2015), Pharma Europe-2015, Spain (2015), 9th Joint Meeting in Medicinal Chemistry, Greece (2015), Nanomaterials and Nanotechnology Meeting, Czech Republic (2015, 2017), 13th Ibn Sina International Conference on Pure and Applied Heterocyclic Chemistry, Egypt (2015), Pharmaceutical Education, Scientific and Manufacturing as a Reference to the Strategy Kazakhstan-2020, Kazakhstan (2014), 6th Conversatory on Medicinal Chemistry, Poland (2014), 7th Central European Conference "Chemistry towards Biology", Poland (2014), Annual International Congress of MediChem, China (2013, 2014, 2016), International Symposium and Workshop on Environment and Health, Czech Republic (2012, 2013), Chromatographic Methods of Investigating the Organic Compounds, Poland (2012–2015, 2017), EU Assessors Training on Efficient and Effective Quality Assessment, Czech Republic (2012)
  • Awards, for example, "Prix de Pharmacie 2004" awarded by Aventis, "Award for Development of Science at the Faculty of Pharmacy of the University of Veterinary and Pharmaceutical Sciences Brno" awarded by the Dean of the Faculty of Pharmacy in 2011, "Outstanding Reviewer 2014–2015 Award" awarded by Wiley-VCH, "Outstanding Contribution in Reviewing 2015 Award" awarded by Elsevier and as a member of teams "Most Cited Paper 2006–2009 Award" awarded by the journal Bioorganic & Medicinal Chemistry, Elsevier and "2011 Industrial Affairs Innovation Award" awarded by Sanofi

 

Selected Peer-reviewed publications

2017

  • Vettorazzi, M.; Angelina, E.; Lima, S.; Goněc, T.; Otevřel, J.; Marvanová, P.; Padrtová, T.; Mokrý, P.; Bobáľ, P.; Acosta, L.M.; Palma, A.; Cobo, J.; Bobáľová, J.; Malík, I.; Alvarez, S.; Spiegel, S.; Jampílek, J.; Enriz, R.D. Search of New Structural Scaffolds for Sphingosine Kinase 1 Inhibitors. Eur. J. Med. Chem. 2017, 139, 461-481.
  • Pížová, H.; Havelková, M.; Štěpánková, Š.; Bąk, A.; Kauerová, T.; Kozik, V.; Oravec, M.; Imramovský, A.; Kollár, P.; Bobáľ, P.; Jampílek, J. Prolin-Based Carbamates as Cholinesterase Inhibitors. Molecules 2017, 22 (11), 1969.
  • Dołowy, M.; Kozik, V.; Bąk, A.; Jampílek, J.; Barbusiński, K.; Thomas, M.; Pyka-Pająk, A. Rapid and Simple TLC-densitometric Method for Assay of Clobetasol Propionate in Topical Solution. Molecules 2017, 22 (11), 1888.
  • Jampílek, J. Design of Antimalarial Agents Based on Natural Products. Curr. Org. Chem. 2017, 21 (18), 1824-1846.
  • Pisárčik, M.; Jampílek, J.; Lukáč, M.; Horáková, R.; Devínsky, F.; Bukovský, M.; Kalina, M.; Tkacz, J.; Opravil, T. Silver Nanoparticles Stabilised by Cationic Gemini Surfactants with Variable Spacer Length. Molecules 2017, 22 (10), 1794.
  • Goněc, T.; Kos, J.; Peško, M.; Doháňošová, J.; Oravec, M.; Liptaj, T.; Kráľová, K.; Jampílek, J. Halogenated 1-Hydroxynaphthalene-2-carboxanilides Affecting Photosynthetic Electron Transport in Photosystem II. Molecules 2017, 22 (10), 1709.
  • Bąk, A.; Kozik, V.; Smoliński, A.; Jampílek, J. In Silico Estimation of Basic Activity-Relevant Parameters for a Set of Drug Absorption Promoters. SAR QSAR Environ. Res. 2017, 28 (6), 427-449.
  • Muráriková, A.; Ťažký, A.; Neugebauerová, J.; Planková, A.; Jampílek, J.; Mučaji, P. Mikuš, P. Characterization of Essential Oils Composition in Different Basil Species and Pot Cultures by GC-MS Method. Molecules 2017, 22 (7), 1221.
  • Goněc, T.; Kráľová, K.; Peško, M.; Jampílek, J. Antimycobacterial N-Alkoxyphenylhydroxynaphthalenecarboxamides Affecting Photosystem II. Bioorg. Med. Chem. Lett. 2017, 27 (9), 1881-1885.
  • Ranjith, P.K.; Mary, S.Y.; Panicker, Y.C.; Anto, P.L.; Armaković, S.; Armaković, S.J.; Musioł, R.; Jampílek, J.; Van Alsenoy, C. New Quinolone Derivative: Spectroscopic Characterization and Reactivity Study by DFT and MD Approaches. J. Mol. Struct. 2017, 1135, 1-14.

2016

  • Pentak, D.; Kozik, V.; Bąk, A.; Dybał, P.; Sochanik, A.; Jampílek, J. Methotrexate and Cytarabine – Loaded Nanocarriers for Multidrug Cancer Therapy. Spectroscopic Study. Molecules 2016, 21 (12), 1689 (12 pages).
  • Pietrzyńska, M.; Zembrzuska, J.; Tomczak, R.; Mikołajczyk, J.; Rusińska-Roszak, D.; Voelkel, A.; Buchwald, T.; Jampílek, J.; Lukáč, M.; Devínský, F. Experimental and In Silico Investigations of Organic Phosphates and Phosphonates Sorption on Polymer-Ceramic Monolithic Materials and Hydroxyapatite. Eur. J. Pharm. Sci. 2016, 93, 295-303
  • Goněc, T.; Pospíšilová, Š.; Holaňová, L.; Stráník, J.; Černíková, A.; Púdelková, V.; Kos, J.; Oravec, M.; Kollár, P.; Čížek, A.; Jampílek, J. Synthesis and Antimicrobial Evaluation of 1-[(2-Substituted phenyl)carbamoyl]naphthalen-2-yl Carbamates. Molecules 2016, 21 (9), 1189 (15 pages).
  • Pietrzyńska, M.; Tomczak, R.; Jezierska, K.; Voelkel, A.; Jampílek, J. Polymer-ceramic Monolithic In-Needle Extraction (MINE) Device: Preparation and Examination of Drug Affinity. Mat. Sci. Eng. C 2016, 68, 70-77.
  • Goněc, T.; Pospíšilová, Š.; Kauerová, T.; Kos, J.; Doháňošová, J.; Oravec, M.; Kollár, P.; Coffey, A.; Liptaj, T.; Čížek,A.; Jampílek, J. N-Alkoxyphenylhydroxynaphthalenecarboxamides and Their Antimycobacterial Activity. Molecules 2016, 21(8), 1068 (18 pages).
  • Jampílek, J. How Can We Bolster the Antifungal Drug Discovery Pipeline? Future Med. Chem. 2016, 8(12), 1393-1397.
  • Bąk, A.; Kozik, V.; Smoliński, A.; Jampílek, J. Multidimensional (3D/4D-QSAR) Probability-Guided Pharmacophore Mapping: Investigation of Activity Profile for a Series of Drug Absorption Promoters. RSC Adv. 2016, 6(80), 76183-76205.
  • Vaculíková, E.; Černíková, A.; Plachá, D.; Pisárčik, M.; Peikertová, P.; Dedková, K.; Devínský, F.; Jampílek, J. Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement. Molecules 2016, 21(8), 1005 (8 pages).
  • Kauerová, T.; Kos, J.; Goněc, T.; Jampílek, J.; Kollár, P. Antiproliferative and Pro-Apoptotic Effect of Novel Nitro-Substituted Hydroxynaphthanilides on Human Cancer Cell Lines. Int. J. Mol. Sci. 2016, 17(8), 1219 (14 pages).
  • Jampílek, J.; Kráľová, K.; Peško, M.; Kos, J. Ring-substituted 8-Hydroxyquinoline-2-carboxanilides as Photosystem II Inhibitors. Bioorg. Med. Chem. Lett. 2016, 26(16), 3862-3865.
  • Marvanová, P.; Padrtová, T.; Pekárek, T.; Brus, J.; Czernek, J.; Mokrý, P.; Humpa, O.; Oravec, M.; Jampílek, J. Synthesis and Characterization of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates and Their Hydrochloride Salts. Molecules 2016, 21(6), 707 (13 pages).
  • Vaculíková, E.; Černíková, A.; Plachá, D.; Pisárčik, M.; Dedková, K.; Peikertová, P.; Devínský, F.; Jampílek, J. Cimetidine Nanoparticles for Permeability Enhancement. J. Nanosci. Nanotechnol. 2016, 16(8), 7840-7843.
  • Pisárčik, M.; Jampílek, J.; Devínsky, F.; Drábiková, J.; Tkacz, J.; Opravil, T. Gemini Surfactants with Polymethylene Spacer: Supramolecular Structures at Solid Surface and Aggregation in Aqueous Solution. J. Surf. Deterg. 2016, 19(3), 477-486.
  • Kushkevych, I.; Kollár, P.; Bartoš, M.; Pauk, K.; Imramovský, A.; Jampílek, J. Antimicrobial Effect of Salicylamide Derivatives Against Intestinal Sulfate-Reducing Bacteria. J. Appl. Biomed. 2016, 14(2), 125-130.
  • Jampílek, J. Potential of agricultural fungicides for antifungal drug discovery. Expert Opin. Drug Dis. 2016, 11 (1), 1-9.

2015

  • Cieslik, W., Spaczyńska, E.; Malarz, K.; Tabak, D.; Nevin, E.; O´Mahony, J.; Coffey, A.; Mrozek-Wilczkiewicz, A.; Jampílek, J.; Musioł, R. Investigation of the Antimycobacterial Activity of 8-Hydroxyquinoline. Med. Chem. 2015, 11 (8), 771-779.
  • Jampílek, J.; Kráľová, K. Application of Nanotechnology in Agriculture and Food Industry, Its Prospects and Risks. Ecol. Chem. Eng. S. 2015, 22 (3), 321-361.
  • Ulahannan, R.T.; Panicker, Y.C.; Varghese, H.T.; Musioł, R.; Jampílek, J.; Van Alsenoy, C.; War, J.A.; Al-Saadi, A.A. Vibrational spectroscopic and molecular docking study of (2E)-N-(4-Chloro-2-oxo-1,2-dihydroquinolin-3-yl)-3-phenylprop-2-enamide. Spectrochim. Acta A 2015, 151, 335-349.
  • Ulahannan, R.T.; Panicker, Y.C.; Varghese, H.T.; Musioł, R.; Jampílek, J.; Van Alsenoy, C.; War, J.A.; Srivastava, S.K. Molecular structure, FT-IR, FT-Raman, NBO, HOMO and LUMO, MEP, NLO and molecular docking study of 2-[(E)-2-(2-bromophenyl)ethenyl]quinoline-6-carboxylic acid. Spectrochim. Acta A 2015, 151, 184-197.
  • Ulahannan, R.T.; Panicker, Y.C.; Varghese, H.T.; Musioł, R.;Jampílek, J.; Van Alsenoy, C.; War, J.A.; Manojkumar, T.K. Vibrational Spectroscopic Studies and Molecular Docking Study of 2-[(E)-2-phenylethenyl]quinoline-5-carboxylic Acid. Spectrochim. Acta A 2015, 150, 190-199.
  • Kos, J.; Zadražilová, I.; Nevin, E.; Šoral, M.; Goněc, T.; Kollár, P.; Oravec, M.; Coffey, A.; O´Mahony, J.; Liptaj, T.; Kráľová, K.;Jampílek, J. Ring-substituted 8-Hydroxyquinoline-2-carboxanilides as Potential Antimycobacterial Agents. Bioorg. Med. Chem. 2015, 23(15), 4188-4196.
  • Zadražilová, I.; Pospíšilová, Š.; Masaříková, M.; Imramovský, A.; Monreal-Férriz, J.; Vinšová, J.; Čížek,A.; Jampílek, J. Salicylanilide Carbamates: Promising Antibacterial Agents with High In Vitro Activity against Methicillin-resistant Staphylococcus aureus (MRSA). Eur. J. Pharm. Sci. 2015, 77, 197-207.
  • Goněc, T.; Zadražilová, I.; Nevin, E.; Kauerová, T.; Peško, M.; Kos, J.; Oravec, M.; Kollár, P.; Coffey, A.; O´Mahony, J.; Čížek,A.; Kráľová, K.; Jampílek, J. Synthesis and Biological Evaluation of N-Alkoxyphenyl-3-hydroxynaphthalene-2-carboxanilides. Molecules 2015, 20 (6), 9767-9787.
  • Vaculíková, E.; Plachá, D.;Jampílek, J. Toxicology of Drug Nanocarriers. Chem. Listy 2015, 109(5), 346-352.
  • Kráľová, K.; Jampílek, J. Impact of Environmental Contaminants on Breast Cancer. Ecol. Chem. Eng. S 2015, 22(1), 9-44.
  • Jampílek, J.; Záruba, K.; Oravec, M.; Kuneš, M.; Babula, P.; Ulbrich, P.; Brezaniová, I.; Opatřilová, R.; Tříska, J.; Suchý, P. Preparation of Silica Nanoparticles Loaded with Nootropics and Their In Vivo Permeation through Blood–Brain Barrier. BioMed Res. Int. 2015, 2015, Article ID 812673 (9 pages).
  • Kos, J.; Nevin, E.; Šoral, M.; Kushkevych, I.; Goněc, T.; Bobál, P.; Kollár, P.; Coffey, A.; O´Mahony, J.; Liptaj, T.; Kráľová, K.; Jampílek, J. Synthesis and Antimycobacterial Properties of Ring-Substituted 6-Hydroxynaphthalene-2-Carboxanilides. Bioorg. Med. Chem. 2015, 23 (9), 2035-2043.
  • Kráľová, K.; Peřina, M.; Waisser, K.; Jampílek, J. Structure-Activity Relationships of N-benzylsalicylamides for Inhibition of Photosynthetic Electron Transport. Med. Chem. 2015, 11 (2), 156-164.
  • Zadražilová, I.; Pospíšilová, Š.; Pauk, K.; Imramovský, A.; Vinšová, J.; Čížek, A.; Jampílek, J. In Vitro Bactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA. BioMed Res. Int. 2015, 2015, Article ID 349534 (8 pages).

2014

  • Jampílek, J. Recent Advances in Design of Potential Quinoxaline Anti-Infectives. Curr. Med. Chem. 2014, 21 (38), 4347-4373.
  • Vaculíková, E.; Plachá, D.; Pisárčik, M.; Peikertová, P.; Dědková, K.; Devínský, F.; Jampílek, J. Preparation of Risedronate Nanoparticles by Solvent Evaporation Technique. Molecules 2014, 19 (11), 17848-17861.
  • Krompiec, S.; Malarz, J.; Pietraszuk, C.; Powała, B.; Rogalski, S.; Małecki, J.G.; Penkala, M.; Filapek, M.; Musioł, R.; Jampílek, J.; Vejsová, M.; Polański, J.; Paluch, M.; Pawlus, S.; Danikiewicz, W.; Kania, M.; Marcol, B. New Strategy for the Synthesis of 3,4,5-Trisubstituted Isoxazolines from Allyl Compounds. Curr. Org. Chem. 2014, 18 (17), 2280-2296.
  • Goněc, T.; Kos, J.; Nevin, E.; Govender, R.; Peško, M.; Tengler, J.; Kushkevych, I.; Šťastná, V.; Oravec, M.; Kollár, P.; O´Mahony, J.; Kráľová, K.; Coffey, A.; Jampílek, J. Preparation and Biological Properties of Ring-Substituted Naphthalene-1-Carboxanilides. Molecules 2014, 19 (7), 10386-10409.
  • Imramovský, A.; Peško, M.; Jampílek, J.; Kráľová, K. Synthesis and Photosynthetic Electron Transport Inhibition of 2-Substituted 6-Fluorobenzothiazoles. Monatsh. Chem. 2014, 145 (11), 1817-1824.
  • Bojňanská, E.; Kalina, M.; Pařízek, L.; Bartoníčková, E.; Opravil, T.; Veselý, M.; Pekař, M.; Jampílek, J. Determination of Critical Parameters of Drug Substance Influencing Dissolution – A Case Study. BioMed Res. Int. 2014, 2014, Article ID 929248 (9 pages).
  • Vaculíková, E.; Plachá, D.; Čech-Barabaszová, K.; Jampílek, J. Cimetidine Nanoparticles Study. Adv. Sci. Eng. Med. 2014, 6 (4), 477-481.
  • Vaverková, V.; Vrána, O.; Adam, V.; Pekárek, T.; Jampílek, J.; Babula, P. The study of Naphthoquinones and its Complexes with DNA by using Raman Spectroscopy and Surface Enhanced Raman Spectroscopy – New Insight into Interactions of DNA with Plant Secondary Metabolites. BioMed Res. Int. 2014, 2014, Article ID 461393 (12 pages).
  • Ulahannan, R.T.; Panicker, Y.C.; Varghese, H.T.; van Alsenoy, C.; Musioł, R.; Jampílek, J.; Anto, P.L. Vibrational Spectroscopic, 1H NMR and Quantum Chemical Computational Study of 4-Hydroxy-2-oxo-1,2-dihydroquinoline-8-carboxylic Acid. Spectrochim. Acta A 2014, 121, 445-456.
  • Ulahannan, R.T.; Panicker, Y.C.; Varghese, H.T.; van Alsenoy, C.; Musioł, R.; Jampílek, J.; Anto, P.L. Spectroscopic (FT-IR, FT-Raman) Investigations and Quantum Chemical Calculations of 4-Hydroxy-2-oxo-1,2-dihydroquinoline-7-carboxylic acid. Spectrochim. Acta A 2014, 121, 404-414.
  • Černíková, A.; Jampílek, J. Structure Modification of Drugs Influencing Their Bioavailability and Therapeutic Effect. Chem. Listy 2014, 108 (1), 7-16.

2013

  • Pauk, K.; Zadražilová, I.; Imramovský, A.; Vinšová, J.; Pokorná, M.; Masaříková, M.; Čížek, A.; Jampílek, J. New Derivatives of Salicylamides: Preparation and Antimicrobial Activity against Various Bacterial Species. Bioorg. Med. Chem. 2013, 21 (21), 6574-6581.
  • Goněc, T.; Kos, J.; Zadražilová, I.; Peško, M.; Keltošová, S.; Tengler, J.; Bobál, P.; Kollár, P.; Čížek, A.; Kráľová, K.; Jampílek, J. Antimycobacterial and Herbicidal Activity of Ring-Substituted 1-Hydroxynaphthalene-2-carboxanilides. Bioorg. Med. Chem. 2013, 21 (21), 6531-6541.
  • Opatřilová, R.; Černíková, A.; Coufalová, L.; Dohnal, J.; Jampílek, J. In vitro permeation of micronized and nanonized alaptide from semi-solid formulations. Sci. World J. 2013, 2013, Article ID 787283 (8 pages).
  • Jampílek, J. Transdermal Application of Drugs and Techniques Affecting Skin Barrier. J. Bioequiv. Availab. 2013, 5 (6), 233-235.
  • Tengler, J.; Kapustíková, I.; Peško, M.; Govender, R.; Keltošová, S.; Mokrý, P.; Kollár, P.; O´Mahony, J.; Coffey, A.; Kráľová, K.; Jampílek, J. Synthesis and Biological evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates. Sci. World J. 2013, 2013, Article ID 274570 (13 pages).
  • Otevřel, J.; Bobál, P.; Zadražilová, I.; Govender, R.; Peško, M.; Keltošová, S.; Kolečkářová, P.; Imramovský, A.; Coffey, A.; O´Mahony, J.; Kollár, P.; Čížek, A.; Kráľová, K.; Jampílek, J. Antimycobacterial and Photosynthetic Electron Transport Inhibiting Activity of Ring-Substituted 4-Arylamino-7-Chloroquinolinium Chlorides. Molecules 2013, 18 (9), 10648-10670.
  • Tengler, J.; Kapustíková, I.; Stropnický, O.; Mokrý, P.; Oravec, M.; Csöllei, J.; Jampílek, J. Synthesis of New (Arylcarbonyloxy)aminopropanol Derivatives and the Determination of Their Physico-Chemical Properties. Cent. Eur. J. Chem. 2013, 11 (11), 1757-1767.
  • Čulen, M.; Řezáčová, A.; Jampílek, J.; Dohnal, J. Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine. J. Pharm. Sci. 2013, 102 (9), 2995-3017.
  • Mrózek, L.; Coufalová, L.; Rárová, L.; Plaček, L.; Opatřilová, R.; Dohnal, J.; Kráľová, K.; Paleta, O.; Král, V.; Drašar, P.; Jampílek, J. New Polyfluorothiopropanoyloxy Derivatives of 5β-Cholan-24-oic Acid Designed as Drug Absorption Modifiers. Steroids 2013, 78 (9), 832-844.
  • Goněc, T.; Kos, J.; Zadražilová, I.; Peško, M.; Govender, R.; Keltošová, S.; Kollár, P.; Imramovský, A.; O´Mahony, J.; Coffey, A.; Čížek, A.; Kráľová, K.; Jampílek, J. Antibacterial and Herbicidal Activity of Ring-Substituted 2-Hydroxynaphthalene-1-carboxanilides. Molecules 2013, 18 (8), 9397-9419.
  • Kos, J.; Zadražilová, I.; Peško, M.; Keltošová, S.; Tengler, J.; Goněc, T.; Bobál, P.; Kauerová, T.; Oravec, M.; Kollár, P.; Čížek, A.; Kráľová, K.; Jampílek, J. Antibacterial and Herbicidal Activity of Ring-Substituted 3-Hydroxynaphthalene-2-carboxanilides. Molecules 2013, 18 (7), 7977-7997.
  • Coufalová, L.; Mrózek, L.; Rárová, L.; Plaček, L.; Opatřilová, R.; Dohnal, J.; Kráľová, K.; Paleta, O.; Král, V.; Drašar, P.; Jampílek, J. New Propanoyloxy Derivatives of 5β-Cholan-24-oic Acid as Drug Absorption Modifiers. Steroids 2013, 78(5), 435-453.
  • Imramovský, A.; Pejchal, V.; Štěpánková, Š.; Vorčáková, K.; Jampílek, J.; Vančo, J.; Šimůnek, P.; Královec, K.; Brůčková, L.; Mandíková, J.; Trejtnar, F. Synthesis and In Vitro Evaluation of New Derivatives of 2-Substituted-6-Fluorobenzo[d]thiazoles as Cholinesterase Inhibitors. Bioorg. Med. Chem. 2013, 21 (7), 1735-1748.

2012

  • Fajkusová, D.; Peško, M.; Keltošová, S.; Guo, J.; Oktábec, Z.; Vejsová, M.; Kollár, P.; Coffey, A.; Csöllei, J.; Kráľová, K.; Jampílek, J. Anti-Infective and Herbicidal Activity of N-Substituted 2-Aminobenzothiazoles. Bioorg. Med. Chem. 2012, 20 (24), 7059-7068.
  • Cieslik, W.; Musioł, R.; Nycz, J.; Jampílek, J.; Vejsová, M.; Wolff, M.; Machura, B.; Polański, J. Contribution to Investigation of Antimicrobial Activity of Styrylquinolines. Bioorg. Med. Chem. 2012, 20 (24), 6960-6968.
  • Vaculíková, E.; Grünwaldová, V.; Král, V.; Dohnal, J.; Jampílek, J. Preparation of Candesartan and Atorvastatin Nanoparticles by Solvent Evaporation. Molecules 2012, 17 (11), 13221-13234.
  • Vaculíková, E.; Grünwaldová, V.; Král, V.; Dohnal, J.; Jampílek, J. Primary Investigation of the Preparation of Nanoparticles by Precipitation. Molecules 2012, 17(9), 11067-11078.
  • Jampílek, J.; Brychtová, K. Azone Analogues: Classification, Design, and Transdermal Penetration Principles. Med. Res. Rev. 2012, 32 (5), 907-947.
  • Imramovský, A.; Štěpánková, Š.; Vančo, J.; Pauk, K.; Monreal-Férriz, J.; Vinšová, J.; Jampílek, J. Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking. Molecules 2012, 17(9), 10142-10158.
  • Kráľová, K.; Jampílek, J.; Ostrovský, I. Metabolomics – Useful Tool for Study of Plant Responses to Abiotic Stresses. Ecol. Chem. Eng. S 2012, 19 (2), 133-161.
  • Zitko, J.; Jampílek, J.; Dobrovolný, L.; Svobodová, M.; Kuneš, J.; Doležal M. Synthesis and antimycobacterial evaluation of N-substituted 3-aminopyrazine-2,5-dicarbonitriles. Bioorg. Med. Chem. Lett. 2012, 22 (4), 1598-1601.
  • Bobál, P.; Šujan, J.; Otevřel, J.; Imramovský, A.; Padělková, Z.; Jampílek, J. Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid. Molecules 2012, 17 (2), 1292-1306.
  • Goněc, T.; Bobál, P.; Šujan, J.; Peško, M.; Guo, J.; Kráľová, K.; Kos, J.; Coffey, A.; Kollár, P.; Imramovský, A.; Plaček, L.; Jampílek, J. Investigating the Spectrum of Biological Activity of Substituted Quinoline-2-Carboxamides and Their Isosteres. Molecules 2012, 17 (1), 613-644.
  • Brychtová, K.; Dvořáková, L.; Opatřilová, R.; Raich, I.; Káčerová, S.; Plaček, L.; Kalinowski, D.; Richardson, D.R.; Jampílek, J. Investigation of Substituted 6-Aminohexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2012, 20 (1), 86-95.

2011

  • Pejchal, V.; Štěpánková, Š.; Padělková, Z.; Imramovský, A.; Jampílek, J. 1,3-Substituted Imidazolidine-2,4,5-triones: Synthesis and Inhibition of Cholinergic Enzymes. Molecules 2011, 16 (9), 7565-7582.
  • Mrózek, L.; Dvořáková, L.; Mandelová, Z.; Rárová, L.; Řezáčová, A.; Plaček, L.; Opatřilová, R.; Dohnal, J.; Paleta, O.; Král, V.; Drašar, P.; Jampílek, J. Investigation of New Acyloxy Derivatives of Cholic Acid and Their Esters as Drug Absorption Modifiers. Steroids 2011, 76 (10-11), 1082-1097.
  • Imramovský, A.; Peško, M.; Monreal-Férriz, J.; Kráľová, K.; Vinšová, J.; Jampílek, J. Photosynthesis-Inhibiting Efficiency of 4-Chloro-2-(chlorophenylcarbamoyl)phenyl alkylcarbamates. Bioorg. Med. Chem. Lett. 2011, 21 (15), 4564-4567.
  • Opletalová, V.; Doležel, J.; Kráľová, K.; Peško, M.; Kuneš, J.; Jampílek, J. Synthesis and Characterization of (Z)-5-Arylmethylidenerhodanines with Photosynthesis-Inhibiting Properties. Molecules 2011, 16 (6), 5207-5227.
  • Kos, J.; Pěntáková, M.; Oktábec, Z.; Krejčík, L.; Mandelová, Z.; Pekárek, T.; Dammer, O.; Tkadlecová, M.; Havlíček, J.; Král, V.; Dohnal, J.; Jampílek, J. Crystallization Products of Risedronate with Carbohydrates and Their Substituted Derivatives. Molecules 2011, 16 (5), 3740-3760.
  • Mandelová, Z.; Opatřilová, R.; Raich, I.; Havlíček, J.; Káčerová, S.; Pekárek, T.; Tkadlecová, M.; Dohnal, J.; Csőllei, J.; Jampílek, J. Synthesis, Physico-Chemical Properties and DFT Calculations of New 2-(4-Arylpiperazine-1-yl)-1-(3-ethylbenzofuran-2-yl)ethanols As Potential Antihypertensive Agents. Curr. Org. Chem. 2011, 15 (7), 1081-1096.
  • Imramovský, A.; Peško, M.; Kráľová, K.; Vejsová, M.; Stolaříková, J.; Vinšová, J.; Jampílek, J. Investigating Spectrum of Biological Activity of 4- and 5-Chloro-2-hydroxy-N-[2-(arylamino)-1-alkyl-2-oxoethyl]benzamides. Molecules 2011, 16 (3), 2414-2430.

2010

  • Oktábec, Z.; Kos, J.; Mandelová, Z.; Pekárek, T.; Řezáčová, A.; Plaček, L.; Tkadlecová, M.; Havlíček, J.; Dohnal, J.; Jampílek, J. Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives. Molecules 2010, 15 (12), 8973-8987.
  • Doležal, M.; Zitko, J.; Osička, Z.; Kuneš, J.; Vejsová, M.; Buchta, V.; Dohnal, J.; Jampílek, J.; Kráľová, K. Synthesis, Antimycobacterial, Antifungal and Photosynthesis-inhibiting Activity of Chlorinated N-phenylpyrazine-2-carboxamides. Molecules 2010,15(12), 8567-8581.
  • Brychtová, K.; Opatřilová, R.; Raich, I.; Kalinowski, D.; Dvořáková, L.; Plaček, L.; Csőllei, J.; Richardson, D.R.; Jampílek, J. Investigating the Activity of 2-Substituted Alkyl-6-(2,5-dioxopyrrolidin-1-yl)hexanoates as Skin Penetration Enhancers. Bioorg. Med. Chem. 2010, 18 (24), 8556-8565.
  • Skórska-Stania, A.; Śliwa, M.; Musílek, K.; Kuča, K.;Jampílek, J.; Musioł, R.; Oleksyn, B.;Dohnal, J. Selected AChE Reactors in Different Crystalline Environment: Salts and Enzyme. Struct. Chem. 2010, 21 (3), 495-501.
  • Mrozek-Wilczkiewicz, A.; Kalinowski, D.; Musioł, R.;Finster, J.; Szurko, A.; Serafin, K.; Knas, M.; Kovacevic, Z.; Jampílek, J.; Ratuszna, A.; Rzeszowska-Wolny J.;Richardson, D.R.; Polański, J. Investigating Anti-proliferative Activity of Styrylazanaphthalenes and Azanaphthalenediones. Bioorg. Med. Chem. 2010, 18(7), 2664-2671.
  • Brychtová, K.; Jampílek, J.; Opatřilová, R.; Raich, I.; Farsa, O.; Csőllei, J. Synthesis, Physico-chemical Properties and Penetration Activity of Alkyl-6-(2,5-dioxopyrrolidin-1-yl)-2-(2-oxopyrrolidin-1-yl)hexanoates as Potential Transdermal Penetration Enhancers. Bioorg. Med. Chem. 2010, 18(1), 73-79.

2009

  • Doležel, J.; Hiršová, P.; Opletalová, V.; Dohnal, J.; Vejsová, M.; Kuneš, J.; Jampílek, J. Rhodanineacetic Acid Derivatives as Potential Drugs: Preparation, Hydrophobic Properties and Antifungal Activity of (5-Arylalkylidene-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acids. Molecules 2009,14 (10), 4197-4212.
  • Opatřilová, R.; Jampílek, J.; Raich, I.; Káčerová, S.; Havlíček, J.; Pekárek, T.; Dohnal, J.; Csőllei, J. Synthesis, Characterization and Physico-chemical Properties of New 2-(4-Arylpiperazine-1-yl)-1-(3-methylbenzofuran-2-yl)ethanoles as Potential Antihypertensive Agents. Curr. Org. Chem. 2009, 13 (10), 965-975.
  • Imramovský, A.; Vinšová, J.; Monreal-Férriz, J.; Doležal, R.; Jampílek, J.; Kaustová, J.; Kunc, F. New Antituberculotics Originated from Salicylanilides with Promising In Vitro Activity against Atypical Mycobacterial Strains. Bioorg. Med. Chem. 2009, 17(10), 3572-3579.
  • Imramovský, A.; Vinšová, J.; Monreal-Férriz, J.; Buchta, V.; Jampílek, J. Salicylanilide Esters of N-protected Amino Acids as Novel Antimicrobial Agents. Bioorg. Med. Chem. Lett. 2009, 19 (2), 348-351.

2008

  • Opletalová, V.; Kalinowski, D.; Vejsová, M.; Kuneš, J.; Pour, M.; Jampílek, J.; Buchta, V.; Richardson, D.R. Identification and Characterization of Thiosemicarbazones with Anti-Fungal and Anti-Tumor Effects: Cellular Iron-Chelation Mediating Cytotoxic Activity. Chem. Res. Toxicol. 2008, 21 (9), 1878-1889.
  • Doležal, M.; Čmedlová, P.; Palek, L.; Vinšová, J.; Kuneš, J.; Buchta, V.; Jampílek, J.; Kráľová, K. Synthesis and Antimycobacterial Evaluation of Substituted Pyrazinecarboxamides. Eur. J. Med. Chem. 2008, 43 (5), 1105-1113.
  • Jampílek, J.; Rečková, Z.; Imramovský, A.; Raich, I.; Vinšová, J.; Dohnal, J. Study of Stability of New Mutual Prodrugs with Antimycobacterial Activity. Curr. Org. Chem. 2008, 12 (8), 667-674.
  • Musioł, R.; Tabak, D.; Niedbala, H.; Podeszwa, B.; Jampílek, J.; Kráľová, K.; Dohnal, J.; Finster, J.; Mencel, A.; Polański, J. Investigating Biological Activity Spectrum for Novel Quinoline Analogues 2: Hydroxyquinolinecarboxamides with Photosynthesis Inhibiting Activity. Bioorg. Med. Chem. 2008, 16 (8), 4490-4499.
  • Palek, L.; Dvořák, J.; Svobodová, M.; Buchta, V.; Jampílek, J.; Doležal, M. Synthesis, Antimycobacterial and Antifungal Evaluation of 3-Arylaminopyrazine-2,5-dicarbonitriles. Arch.Pharm. 2008, 341 (1), 61-65.
  • Vinšová, J.; Imramovský, A.; Jampílek, J.; Monreal-Férriz, J.; Doležal, M. Recent Advances on Isoniazide Derivatives. Anti-Infective Agents Med. Chem. 2008, 7 (1), 12-31.

2007

  • Podeszwa, B.; Niedbala, H.; Polański, J.; Musioł, R.; Tabak, D.; Finster, J.; Serafin, K.; Wietrzyk, J.; Boryczka, S.; Mól, W.; Jampílek, J.; Dohnal, J.; Kalinowski, D.; Richardson, D.R. Investigating the Antiproliferative Activity of Quinoline-5,8-dione Analogues on Tumour Cell Lines. Bioorg. Med. Chem. Lett. 2007, 17 (22), 6138-6141.
  • Jampílek, J.; Doležal, M.; Buchta, V. Antimicrobial Evaluation of Some Arylsulfanylpyrazinecarboxylic Acid Derivatives. Med. Chem. 2007, 3 (3), 277-280.
  • Imramovský, A.; Polanc, S.; Vinšová, J.; Kočevar, M.; Jampílek, J.; Kaustová, J. A New Modification of Antitubercular Active Molecules. Bioorg. Med. Chem. 2007,15 (7), 2551-2559.
  • Musioł, R.; Jampílek, J.; Kráľová, K.; Richardson, D.R.; Kalinowski, D.; Podeszwa, B.; Finster, J.; Niedbala, H.; Pałka, A.; Polański, J. Investigating Biological Activity Spectrum forNovel Quinoline Analogues. Bioorg. Med. Chem. 2007, 15(3), 1280-1288.

2006

  • Vinšová, J.; Čermáková, K.; Tomečková, A.; Čečková, M.; Jampílek, J.; Čermák, P.; Kuneš, J.; Doležal, M.; Štaud, F. Synthesis and Antimicrobial Evaluation of New 2-Substituted 5,7-Di-tert-butylbenzoxazoles. Bioorg. Med. Chem. 2006,14(17), 5850-5865.
  • Musioł, R.; Jampílek, J.; Buchta, V.; Silva, L.; Niedbala, H.; Podeszwa, B.; Pałka, A.; Majerz-Maniecka, K.; Oleksyn, B.; Polański, J. Antifungal Properties of New Series of Quinoline Derivatives. Bioorg. Med. Chem. 2006,14(10), 3592-3598.
  • Doležal, M.; Palek, L.; Vinšová, J.; Buchta, V.; Jampílek, J.; Kráľová, K. Substituted Pyrazinecarboxamides: Synthesis and Biological Evaluation. Molecules 2006,11 (4), 242-256.
  • Jampílek, J.; Doležal, M.; Opletalová, V.; Hartl, J. 5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents. Curr. Med. Chem. 2006, 13 (2), 117-129.

2005–2003

  • Jampílek, J.; Doležal, M.; Kuneš, J.; Buchta, V.; Silva, L.; Kráľová, K. Quinaldine Derivatives: Preparation and Biological Activity. Med. Chem. 2005, 1 (6), 591-599.
  • Jampílek, J.; Doležal, M.; Kuneš, J.; Šatínský, D.; Raich, I. Novel Regioselective Preparation of 5-Chloropyrazine-2-carbonitrile from Pyrazine-2-carboxamide and Coupling Study of Substituted Phenylsulfanylpyrazine-2-carboxylic Acid Derivatives. Curr. Org. Chem. 2005, 9 (1), 49-60.
  • Jampílek, J.; Doležal, M.; Kuneš, J.; Víchová, P.; Jun, D.; Raich, I.; O´Connor, R.; Clynes, M. Preparation of 2-(4-{[4-(Quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic Acid (VUFB 20615) and 2-Methyl-2-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionic Acid (VUFB 20623) as Potential Antileukotrienic Agents. Curr. Org. Chem. 2004, 8 (13), 1235-1243.
  • Jampílek, J.; Doležal, M.; Kuneš, J.; Víchová, P.; Jun, D.; Hanika, J.; O´Connor, R.; Clynes, M. Synthesis of (2E)-2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)prop-2-enoic Acid (VUFB 20609) and 2-Methyl-3-(4-{[4-(quinolin-2-ylmethoxy)phenyl]sulfanyl}phenyl)propionicAcid (VUFB 20584) as Potential Antileukotrienic Agents. J. Pharm. Pharmacol. 2004, 56 (6), 783-794.
  • Doležal, M.; Jampílek, J.; Osička, Z.; Kuneš, J.; Buchta, V.; Víchová, P. Substituted 5-Aroylpyrazine-2-carboxylic Acid Derivatives: Synthesis and Biological Activity. Farmaco 2003, 58 (11), 1105-1111.

 

Selected Patents:

  • Jampílek, J.; Goněc, T.; Kos, J.; Pospíšilová, Š.; Michnová, H.; Čížek, A.; Coffey, A. Utilization of Novel Multisubstituted Hydroxynaphthalenes Derivatives as Antimycobacterial Compounds. Slovak Patent PP 71-2017, July 28, 2017.
  • Jampílek, J.; Goněc, T.; Pospíšilová, Š.; Čížek, A.; Enriz, R.D.; Feresin, G.E.; Andujar, S.A.; Gutierrez, L.J.; Kapustíková, I.; Kos, J. Utilization of Novel Multisubstituted Naphthalene Derivatives as Broad-spectrum Antibacterial Compounds. Slovak Patent PP 65-2017, July 17, 2017.
  • Jampílek, J.; Goněc, T.; Musioł, R.; Spaczyńska, E.; Malarz, K.; Mrozek-Wilczkiewicz, A.; Kapustíková, I. Utilization of New Antitumoral Naphthalene Derivatives Effective in Treatment of Colon Cancer. Slovak Patent PP 64-2017, July 17, 2017.
  • Jampílek, J.; Opatřilová, R.; Dvořáková, L.; Dohnal, J. Utilization of Alaptide as Transdermal Penetration Modifier in Pharmaceutical Compositions for Human and Veterinary Applications Containing Glucocorticoids. CZ 306770 B6, May 17, 2017
  • Jampílek, J.; Opatřilová, R.; Dvořáková, L.; Černíková, A.; Dohnal, J. Utilization of Alaptide as Transdermal Penetration Modifier in Pharmaceutical Compositions for Human and Veterinary Applications Containing Antimicrobial Chemotherapeutics. CZ 306686 B6, March 29, 2017.
  • Kozakiewicz, D.; Polański, J.; Jampílek, J.; Imramovský, A.; Štěpánková, Š. New Carbamates and Their Use. Polish Patent P.420629, February 23, 2017.
  • Kozakiewicz, D.; Polański, J.; Jampílek, J.; Imramovský, A.; Štěpánková, Š. New Carbamate Derivatives and Their Application. Polish Patent P.420626, February 23, 2017.
  • Mrozek-Wilczkiewicz, A.; Malarz, K.; Musioł, R.; Spaczyńska, E.; Krzykała, K.; Jampílek, J. New Naphthalene Derivatives and Their Application. Polish Patent P.419318, October 31, 2016.
  • Jampílek, J.; Opatřilová, R.; Dvořáková, L.; Brychtová, K.; Dohnal, J. Utilization of Alaptide as Transdermal Penetration Modifier in Pharmaceutical Compositions for Human and Veterinary Applications Containing Non-steroidal Anti-Inflammatory and/or Antipyretic-Analgesic Drugs. CZ 304915 B6, December 10, 2014.
  • Jampílek, J.; Opatřilová, R.; Řezáčová, A.; Oktábec, Z.; Dohnal, J. Alaptide: Methods of Effecting its Solubility, Membrane Permeation and Pharmaceutical Compositions for Human and/or Veterinary Applications.WO/2014/019556 A1, February 06, 2014.
  • Jampílek, J.; Opatřilová, R.; Coufalová, L.; Černíková, A.; Dohnal, J. Utilization of Alaptide as Transdermal Penetration Modifier in Pharmaceutical Compositions for Human and Veterinary Applications Containing Anti-Inflammatory Drugs and/or Antimicrobial Chemotherapeutics. WO/2013/020527A1, February 14, 2013.
  • Král, V.; Oktábec, Z.; Jampílek, J.; Pekárek, T.; Proksa, B.; Dohnal, J.; Malovíková, A.; Ebringerová, A.; Řezáčová, A. Increase of API water-solubility and colon targeted drug delivery systems. CZ 302789 B6, September 29, 2011.
  • Mudra, P.; Pokorný, V.; Pešek, V.; Poncar, P.; Bárta, J.; Řezáčová, A.; Jampílek, J.; Dohnal, J.; Král, V. Digestive Tract Simulator. WO/2011/069472A1, June 16, 2011.
  • Král, V.; Oktábec, Z.; Jampílek, J.; Pekárek, T.; Proksa, B.; Dohnal, J.; Malovíková, A.; Ebringerová, A.; Řezáčová, A.. Pectin Complexes of Sartans and Pharmaceutical Compositions Based Thereon. WO/2011/063775A2, June 03, 2011.
  • Král, V.; Oktábec, Z.; Jampílek, J.; Pekárek, T.; Proksa, B.; Dohnal, J.; Malovíková, A.; Ebringerová, A.; Řezáčová, A. Pectin complexes of steroids and pharmaceutical compositions based thereon. WO/2011/063774A2, June 03, 2011.
  • Mudra, P.; Pokorný, V.; Pešek, V.; Poncar, P.; Bárta, J.; Řezáčová, A.; Jampílek, J.; Dohnal, J.; Král, V. Digestive Tract Simulator. CZ 302422 B6, March 30, 2011.
  • Král, V.; Brusová, H.; Jampílek, J.; Havlíček, J.; Pekárek, T.; Tkadlecová, M. Imatinib Mesylate Polymorphs Generated by Crystallization in Aqueous Inorganic Salt Solutions. WO/2011/023146A1, March, 03, 2011.
  • Král, V.; Jampílek, J.; Havlíček, J.; Brusová, H.; Pekárek, T. Dosage Forms of Tyrosine Kinase Inhibitors. WO/2010/081443A2, July, 22, 2010.
  • Svoboda, M.; Jampílek, J.; Kačírková, M.; Tomášek, V.; Lehocký, M.; Hejtmánková, L.; Vosátka, V. Crystalline Tolterodine Tartarate and a Pharmaceutical Composition Containing the Same. WO/2008/017278A3, August 28, 2008.
  • Musioł, R.; Jampílek, J.; Buchta, V.; Kráľová, K.; Finster, J.; Podeszwa, B.; Tabak, D.; Polański, J. Quinazoline derivatives as fungicides and herbicides and their application. PL 379252 A1, October 01, 2007.
  • Svoboda, M.; Jampílek, J.; Kačírková, M.; Tomášek, V.; Lehocký, M. Pharmaceutical composition containing tolterodine. CZ 298448 B6, August 24, 2007.
  • Svoboda, M.; Jampílek, J.; Šebek, P. Pharmaceutical composition of clopidogrel hydrogenbromide. CZ 298349 B6, July 25, 2007.
  • Musioł, R.; Jampílek, J.; Buchta, V.; Niedbala, H.; Pałka, A.; Podeszwa, B.; Polański, J.Quinoline derivatives acting activity as fungicides and their application. PL 375805 A1, December 27, 2006.
  • Musioł, R.; Jampílek, J.; Kráľová, K.; Niedbala, H.; Pałka, A.; Podeszwa, B.; Polański, J. Derivatives of quinoline featuring activity as herbicides and algicides, their precursors, methods for their manufacture and their applications. PL 375678 A1, December 27, 2006.

 

Books and book chapters:

  • Jampílek, J.; Kráľová, K. Impact of Nanoparticles on Living Organisms and Human Health. In: Encyclopedia of Nanoscience and Nanotechnology. Hari S. Nalwa (Ed.). American Scientific Publishers, USA, 2018. [ISBN 1-58883-212-0]
  • Jampílek, J.; Kráľová, K. Nanomaterials Applicable in Food Protection. In: Nanotechnology Applications in the Food Industry. Ravishankar R. Vittal and Jamuna A. Bai (Eds.). Taylor & Francis Group, Boca Raton, FL, USA, 2018, Chapter 5, 75-96. [ISBN 978-1-4987-8483-2]
  • Jampílek, J.; Kráľová, K. Application of Nanobioformulations for Controlled Release and Targeted Biodistribution of Drugs. In: Nanobiomaterials: Applications in Drug Delivery. Anil K. Sharma, Raj K. Keservani, Rajesh K. Kesharwani (Eds.). CRC Press, Waretown, NJ, USA, 2017, Part II, Chapter 5, 131-208. [ISBN 978-1-77-188591-1]
  • Jampílek, J.; Kráľová, K. Nanomaterials for Delivery of Nutrients and Growth-Promoting Compounds to Plants. In: Nanotechnology: An Agricultural Paradigm. Ram Prasad, Manoj Kumar, and Vivek Kumar (Eds.). Springer-Verlag Berlin Heidelberg, Germany, 2017, Chapter 9, 177-226. [ISBN 978-981-10-4572-1]
  • Jampílek, J.; Kráľová, K. Nano-antimicrobials: Activity, benefits and weaknesses. In: Nanostructures in Therapeutic Medicine, Vol. 2 – Nanostructures for Antimicrobial Therapy. Anton Ficai, Alexandru M. Grumezescu (Eds.). Elsevier, Amsterdam, Netherlands, 2017, Chapter 2, 23-54. [ISBN 978-0-323-46152-8]
  • Jampílek, J.; Kráľová, K. Nanopesticides: Preparation, Targeting and Controlled Release. In: Nanotechnology in the Agri-Food Industry, Vol. 10 – New Pesticides and Soil Sensors. Alexandru M. Grumezescu (Ed.). Academic Press & Elsevier, London, UK, 2017, Chapter 3, 81-127. [ISBN 978-0-12-804299-1]
  • Jampílek, J.; Dohnal, J. Alaptide as Transdermal Permeation Modifier. In: Percutaneous Penetration Enhancers, Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. Nina Dragicevic-Curic, Howard I. Maibach (Eds.). Springer-Verlag Berlin Heidelberg, Germany, 2015, Chapter 8, p. 115-132. [ISBN 978-3-662-47038-1]
  • Jampílek, Josef. Azone and Its Analogues. In: Percutaneous Penetration Enhancers, Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum. Nina Dragicevic-Curic, Howard I. Maibach (Eds.). Springer-Verlag Berlin Heidelberg, Germany, 2015, Chapter 6, p. 69-106. [ISBN 978-3-662-47038-1]
  • Jampílek, J.; Dohnal, J. Investigation of Carbohydrates and Their Derivatives as Crystallization Modifiers. In: Carbohydrates – Comprehensive Studies on Glycobiology and Glycotechnology. Chuan-Fa Chang (Ed.). InTech, Rijeka, Croatia, 2012, Chapter 5, pp. 81-116. [ISBN 979-953-307-908-9]
  • Doležal, M.; Zitko, J.; Jampílek, J. Pyrazinecarboxylic Acid Derivatives with Antimycobacterial Activity. In: Understanding Tuberculosis – New Approaches to Fighting Against Drug Resistance. Pere-Joan Cardona (Ed.). InTech, Rijeka, Croatia, 2012, Chapter 10, pp. 233-262. [ISBN 978-953-307-948-6]
  • Dohnal, J.; Jampílek, J.; Řezáčová, A.; Plaček, L.; Grünwaldová, V.; Brusová, H.; Havlíček, J.; Pekárek, T.; Grafnetterová, T.; Opatřilová, R.; Krumbholcová, L.; Setnička, V.; Urbanová M.; Král, V. Modern Approaches to Pharmaceutical Analysis (in Czech). Jiří Dohnal, Josef Jampílek, Vladimír Král, Anna Řezáčová (Eds.). Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic, 2010, 500 pp. [ISBN 978-80-7305-085-6]