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     Associate Professor Dr. Ladislav Habala

 Academic background

Graduation: Slovak Technical University in Bratislava, Slovakia (specialization Organic Chemistry)

Doctoral degree: University of Vienna (Austria), Institute of Bioinorganic Chemistry (doctoral thesis: Synthesis of Novel Derivatives of Oxaliplatin)

Habilitation (Associated Professor): Faculty of Pharmacy, Comenius University in Bratislava, Slovakia (specialization: Pharmaceutical Chemistry, thesis: Selected Metallopharmaceuticals with Antimicrobial and Antineoplastic Effect)

Research interests

• bioinorganic chemistry and metallodrugs
• chemistry of vanadium
• pharmaceutical chemistry
• anticancer and antimicrobial chemotherapy
• chiral compounds in chemistry and pharmacology

Current research

• synthesis and investigation of metal complexes with antimicrobial/anticancer effects and other activities - antioxidative, enzyme inhibitory, etc., in particular complexes with bioactive ligands such as NSAIDs (more)
• preparation, enantioseparation and enantioselective bioactivity of chiral compounds of medical importance

Courses given

• General and Inorganic Chemistry
• Selected Chapters in Inorganic Chemistry
• Metallopharmaceuticals and Nanoparticles as Modern Drugs
• Advanced Materials and Nanoparticles in Medicinal Chemistry 

Lecture notes / textbooks

Chemical Calculations and Introduction to Laboratory Work in General and Inorganic Chemistry

Laboratory Techniques and Syntheses in Organic Chemistry

International experience

Institute of Inorganic Chemistry
University of Vienna, Austria

Institute of Biophysical Chemistry
University of Vienna, Austria

Institute of Bioinorganic and Radiopharmaceutical Chemistry
Research Centre Rossendorf, Dresden, Germany

Institute of Organic Chemistry
University of Leipzig, Germany

 Other professional activities

Organizer (chairman) of the conference Synthesis and Analysis of Drugs

Member of the Slovak Chemical Society

 

Selected publications

Čižmáriková R, Valentová J, Polakovičová M, Habala L: Antioxidant activity of novel phenolic compounds bearing basic substituents – synthesis and insights from molecular modelling. European Pharmaceutical Journal (2026) in press.

Habala L, Džongov A: Novel non-arene osmium complexes with anticancer activity – a brief survey of the last decade. Crystals 16 (2026) 94. doi:10.3390/cryst16020094

Čižmáriková R, Habala L, Valentová J.  General anesthetics: aspects of chirality, pharmacodynamics, and pharmacokinetics. Pharmaceuticals 18 (2025) 250. doi:10.3390/ph18020250

Oboňová B, Valentová J, Litecká M, Pašková Ľ, Hricovíniová J, Bilková A, Bilka F, Horváth B, Habala L. Novel copper(II) complexes with fluorine-containing reduced Schiff base ligands showing marked cytotoxicity in a cancer cell line. International Journal of Molecular Sciences, 25 (2024) 9166. doi:10.3390/ijms25179166

Čižmáriková R, Habala L, Valentová J. Auxiliary drugs (benzodiazepines, opioid analgesics, presynaptic α2-adrenergic receptor agonists, peripheral myorelaxants) used in general anesthesia. Česká a Slovenská Farmacie 73 (2024) e1-e14. doi:10.36290/csf.2024.019

Čižmáriková R, Habala L, Valentová J, Némethy A, Bruchatá K, Hroboňová K. Synthesis, antioxidant activity and HPLC enantioseparation of aryloxyaminopropanols derived from naphthalen-2-ol. European Pharmaceutical Journal 70 (2023) 20-30. doi:10.2478/afpuc-2023-0015

Oboňová B, Habala L, Litecká M, Herich P, Bilková A, Bilka F, Horváth B. Antimicrobially active Zn(II) complexes of reduced Schiff bases derived from cyclohexane-1,2-diamine and fluorinated benzaldehydes—synthesis, crystal structure and bioactivity. Life 13 (2023) 1516. doi:10.3390/life13071516

Čižmáriková R, Habala L, Markuliak M. General intravenous anesthetics – pharmacodynamics, pharmacokinetics and chiral properties. Česká a Slovenska Farmacie 72 (2023) 155–164. doi:10.5817/CSF2023-4-155

Valentová J, Lintnerová L, Miklášová N, Oboňová B, Habala L. Analogues of anticancer natural products: chiral aspects. International Journal of Molecular Sciences 24 (2023) 5679. doi:10.3390/ijms24065679

Čižmáriková R, Valentová J, Habala L, Konušová L.Synthesis, antioxidative activity and enantioseparation of aryloxyaminopropanols derived from 3-methylphenol – bevantolol, toliprolol and a pyrazolidine derivative. Farmaceutický Obzor 90 (2021) 137-143.

Habala L, Pašková Ľ, Bilková A, Bilka F, Oboňová B, Valentová J: Antimicrobial activity and cytotoxicity of transition metal carboxylates derived from agaric acid. European Pharmaceutical Journal 68 (2021) 46-53. doi:10.2478/afpuc-2020-0018

Čižmáriková R, Habala L, Valentová J, Šmátralová D: Synthesis and HPLC enantioseparation of novel derivatives of 3-alkoxy-4-hydroxyphenylalkanones of a potential α/β-blocker type. Česká a Slovenská Farmacie [Czech and Slovak Pharmacy] 70 (2021) 51-58. (download)

Čižmáriková R, Habala L, Markuliak M: General inhalational anesthetics – pharmacodynamics, pharmacokinetics and chiral properties.  Česká a Slovenská Farmacie [Czech and Slovak Pharmacy] 70 (2021) 7-17. (download)

Čižmáriková R, Markuliak M, Habala L, Valentová J, Bilková A: Synthesis, antimicrobial and antiradical activity of (3-alkoxymethyl-4-hydroxyphenyl)propan-1-ones intermediates of biologically active compounds and activity comparison with 3-(alkoxymethyl)-4-(alkylamino-2-hydroxypropoxyphenyl)alkanones type of  beta-blockers. European Pharmaceutical Journal 67 (2020) 34-44. doi:10.2478/afpuc-2020-0012

Čižmáriková R, Čižmárik J, Valentová J, Habala L, Markuliak M: Chiral aspects of local anesthetics. Molecules 25 (2020) 2738. doi:10.3390/molecules25122738

Habala L, Valentová J: Metal complexes in medicine and pharmacy – the past and the present III.  Česká a Slovenská Farmacie [Czech and Slovak Pharmacy] 69 (2020) 121-129. (download)

Habala L, Valentová J: Metal complexes in medicine and pharmacy – the past and the present II. Česká a Slovenská Farmacie [Czech and Slovak Pharmacy] 69 (2020) 3-16. (download)

Čižmáriková R, Habala L, Markuliak M, Valentová J: Survey of pharmacological activity and pharmacokinetics of selected β-adrenergic blockers in regard to their stereochemistry. Applied Sciences 9 (2019) 625. doi:10.3390/app9040625

Valentová J, Varényi S, Herich P, Baran P, Bilková A, Kožíšek J, Habala L: Synthesis, structures and biological activity of copper(II) and zinc(II) Schiff base complexes derived from aminocyclohexane-1-carboxylic acid. New type of geometrical isomerism in polynuclear complexes. Inorganica Chimica Acta 480 (2018) 16-26. doi:10.1016/j.ica.2018.04.058

Habala L, Devínsky F, Egger AE: Metal complexes as urease inhibitors. Journal of Coordination Chemistry 71 (2018) 907-940. doi:10.1080/00958972.2018.1458228

Čižmáriková R, Némethy A, Habala L, Račanská E, Valentová J, Hroboňová K: Synthesis, pharmacological activity and chromatographic enantioseparation of new heterocyclic compounds of the aryloxyaminopropanol  type derived from 4-hydroxyphenylalkanones.  Monatshefte für Chemie – Chemical Monthly 149 (2018) 969-976. doi:10.1007/s00706-018-2185-z

Habala L, Horáková R, Čižmáriková R: Chromatographic separations based on tartaric acid and its derivatives. Monatshefte für Chemie – Chemical Monthly 149 (2018) 873–882. doi:10.1007/s00706-018-2160-8

Habala L, Valentová J: Metal complexes in medicine and pharmacy – the past and the present I. Czech and Slovak Pharmacy [Česká a Slovenská Farmacie] 67 (2018) 182-191. (download)

Valentová J, Habala L: Application of direct analysis in real time – mass spectrometry (DART-MS) on designer drug identification. Chapter 10 in Advances in Medicine and Biology, Vol. 116 (editor  L. V. Berhardt), p. 201-229, Nova Science Publishers, 2017. ISBN: 978-1-53610-906-1

Čižmáriková R, Habala L, Horáková R: Tartaric acid and its derivatives as chiral selectors in stereoselective synthesis and analysis. Chapter 3 in Advances in Chemistry Research, Vol. 41 (editor James C. Taylor), p. 201-247, Nova Science Publishers, 2017. ISBN: 978-1-53612-861-1

Habala L, Valentová J, Pechová I, Fuknová M, Devínsky F: DART - LTQ ORBITRAP as an expedient tool for the identification of synthetic cannabinoids. Legal Medicine 20 (2016) 27-31. doi:10.1016/j.legalmed.2016.03.006

Habala L, Varényi S, Bilková A, Herich P, Valentová J, Kožíšek J, Devínsky F: Antimicrobial activity and urease inhibition of Schiff bases derived from isoniazid and fluorinated benzaldehydes and of their copper(II) complexes. Molecules 21 (2016) 1742. doi:10.3390/molecules21121742

Bruchatá K, Némethy A, Čižmáriková R, Račanská E, Habala L: Synthesis and in vitro pharmacological evaluation of 5-(alkoxymethyl)-2-(3-alkylamino-2-hydroxypropoxy)phenylethanones related to acebutolol and celiprolol. Archiv der Pharmazie 349 (2016) 733-740. doi:10.1002/ardp.201600136

Habala L, Bartel C, Giester G, Jakupec MA, Keppler BK, Rompel A: Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium – synthesis, structure and bioactivity of the vanadium complex. Journal of Inorganic Biochemistry 147 (2015) 147-152. doi:10.1016/j.jinorgbio.2015.04.004

Valentová J, Habala L, Kubincová J, Nemec A, Devínsky F. Direct and rapid analysis of synthetic cannabinoids by real-time-mass spectrometry (DART-MS). Proceedings of the 12th International Forensic Symposium, Bratislava 2015, 8 p.

Habala L, Roller A, Matuška M, Valentová J, Rompel A, Devínsky F. Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with copper(II) and cobalt(II): preparation, crystal structure and urease inhibitory activity. Inorganica Chimica Acta 421 (2014) 423–426. doi:10.1016/j.ica.2014.06.035

Grman M, Mišák A, Jacob C, Tomášková Z, Bertová A, Burkholz T, Dočolomanský P, Habala L, Ondriaš K. Low molecular thiols, pH and O2 modulate H2S-induced S-nitrosoglutathione decomposition-•NO release. General Physiology and Biophysics 32 (2013) 429-441.doi:10.4149/gpb-2013026

Habala, L.; Bartel, C.; Giester, G.; Ionita, G.; Jakupec, M.; Valentová, J.; Keppler, B. K.; Rompel, A.; Devínsky F.: Preparation, characterization and bioactivity of a novel oxovanadium complex. Monograph Series of the International Conferences on Coordination Chemistry held periodically at Smolenice in Slovakia, 10 (2011) 124-132.

Abramkin SA, Jungwirth U, Valiahdi SM, Dworak C, Habala L, Meelich K, Berger W, Jakupec MA, Hartinger CG, Nazarov AA, Galanski M, Keppler BK. {(1R,2R,4R)-4-Methyl-1,2-cyclohexanediamine}oxalatoplatinum(II) - a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo. Journal of Medicinal Chemistry 53 (2010) 7356-7364. doi:10.1021/jm100953c

Habala L, Dworak C, Nazarov AA, Hartinger CG, Abramkin SA, Arion VB, Lindner W, Galanski M, Keppler BK. Methyl-substituted trans-1,2-cyclohexanediamines as new ligands for oxaliplatin-type complexes. Tetrahedron 64 (2008) 137-146. doi:10.1016/j.tet.2007.10.069

Habala L, Galanski M, Yasemi A, Nazarov AA, Keyserlingk N. Graf von, Keppler BK. Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives. European Journal of Medicinal Chemistry 40 11 (2005) 1149-1155. doi:10.1016/j.ejmech.2005.06.003

Galanski M, Habala L, Nazarov AA, Jakupec MA, Yasemi A, Slaby S, Graf von Keyserlingk N, Keppler BK. Rational development of oxaliplatin analogues - synthesis and preliminary structure-activity relationships. International Journal of Clinical Pharmacology and Therapeutics 43 (2005) 575-576. doi:10.5414/CPP43575

Rappel C, Galanski M, Yasemi A, Habala L, Keppler BK. Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients. Electrophoresis  26 (2005) 878-884. doi:10.1002/elps.200410053

Habala L, Zessin J, Steinbach J. Synthesis of McN5652 derivatives as PET tracers for the serotonin transporter. Wissenschaftlich-technische Berichte FZR 363 (2003) 38.

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